Fatal Familial Insomnia: A Rare Genetic Disorder That Affects Sleep

Fatal Familial Insomnia (FFI) is a rare genetic disorder that affects sleep. According to key facts, the disease is inherited from parent to child and is caused by a genetic mutation in the PRNP gene. It is estimated that only 1 to 2 people per million are affected by FFI every year. The symptoms of FFI include insomnia, memory loss, high blood pressure, hallucinations, involuntary jerking or twitching of muscles, profuse sweating, loss of coordination and concentration. The age of onset for FFI can vary, typically occurring in individuals in their 40s, but can also develop in the 20s or as late as 70. The duration of the disease is typically 9 to 30 months after symptoms emerge. Unfortunately, there is no cure for FFI, and treatment can only slow down the progression of symptoms. The disorder is a serious condition that affects the quality of life for those affected, and it is essential to raise awareness about FFI to help those living with the disease.